Health, Nutraceutical

Water-soluble components of Turmeric for joint health

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In the next five years, the global market for bone and joint health ingredients is forecast to grow at a rate of 6.3% (CAGR), mainly due to the graying populations of the developed world. It is projected to reach 3.5 billion U.S. dollars by 2024. While older people are the primary drivers of the joint health market, athletes and weekend warriors are feeling the short term effects of vigorous exercise on their joints. They are also looking for proactive solutions to help prevent deterioration later in life.

There are various remedies for joint pain and stiffness, but they all have their limitations. Pharmaceuticals, such as nonsteroidal anti-inflammatory drugs (NSAIDs), often have dangerous side effects when used long term. Collagen requires doses high enough to be cumbersome, the scientific evidence for glucosamine is mixed, and there are sustainability problems with the harvesting of Boswellia.

Turmeric is a leading botanical ingredient for joint health. The most popular and researched component of turmeric is curcumin. Although curcumin is well studied for its bioactivity, formulators face significant challenges due to its extremely low bioavailability. Curcumin is not soluble in the aqueous environment of the gastrointestinal tract, due to its polarity and reduced dissolution rate. As a result, it is poorly absorbed in the system. In addition to the bioavailability issue, curcumin is typically extracted with harsh industrial solvents, a concern for many consumers in the age of clean-label products.

Consumers are looking for safe, natural, effective, and convenient solutions for joint health.  Is the answer a different kind of turmeric extract?

At Natural Remedies, we were on a quest to discover these unexplored components of turmeric. After years of research by our team of herbalists and scientists, we found that turmeric also contains a particular class of water-soluble polysaccharides that are potent, promising, and bioactive, which led to the discovery of our patented extract; Turmacin®

The efficacy of Turmacin® for joint health is substantiated by five clinical studies and seven preclinical studies. Studies have shown that Turmacin® reduces joint pain, and it works quickly (within three hours) with long-lasting (continuing for 24 hours) effects.

Turmacin® exerts its activity through multiple modes of action. It reduces markers of collagen degradation (IL-6, IL-8, COX-2, PGE2, TNF-alpha, ICAM-1) in human articular cartilage cells. It also lowers cartilage damage by increasing gene expression of type II collagen, decreasing gene expression of MMP-3 and MMP-7, and by protecting glycosaminoglycans. It is also known to inhibit NF-kappa-beta, a protein complex implicated in chronic inflammation, and slows hydrogen peroxide-induced aging of cartilage cells. These combined actions slow the degradation of existing cartilage while supporting the synthesis of new cartilage, helping to keep these natural processes in a healthy balance.

Turmacin® is active at a dose of 500 mg per day, and it’s Non-GMO Project verified, available with USDA and EU organic certification.

Besides traditional dosage forms like capsules and tablets, Turmacin® can also be formulated as functional beverages and functional foods due to its GRAS status.

Innovate your formulation with Turmacin® and think beyond curcumin for Joint Health.

Learn more: Click here

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